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P06.08-YI

EFFECT OF RECK GENE POLYMORPHISMS ON
HEPATOCELLULAR CARCINOMA SUSCEPTIBILITY AND
PROGRESSION IN EGYPTIAN PATIENTS

Ahmed M. El-Sayed Ahmed El Nakib , Sally A. AbdEL Aziz 2
* 1
2
1 Tropical Medicine, Mansoura University Hospitals, Medical Biochemistry Dept., Mansoura
Faculty of Medicine, Mansoura, Egypt
Corresponding author’s email: el_naqueeb@yahoo.com

Introduction: Hepatocellular carcinoma (HCC) is the fifth most common cause of
cancer worldwide. In Egypt, HCC was reported to account for about 4.7% of chronic liver
disease (CLD) patients. The reversion-inducing-cysteine-rich protein with Kazal motifs
(RECK) gene is a transformation suppressor gene against activated ras oncogenes. RECK
gene may play a role in carcinogenesis and metastasis.

Aims: To analyze the association between RECK gene single nucleotide polymorphisms
(SNPs) and hepatocellular carcinoma susceptibility and progression among the Egyptian ePOSTER ABSTRACTS
patients.

Material and Methods: RECK gene rs16932912 SNP and rs11788747 SNP were
estimated using real-time PCR technique in 100 adult Egyptian patients with HCC ( 50
patients have tumor size > 4 cm and 50patients with tumor size< 4 cm and 200 healthy
control subjects

Results: Rs16932912 polymorphism on HCC:
There was significant decrease in the frequency of the homozygous GG genotype of
rs16932912 polymorphism in studied HCC cases < 4cm as compared to that of control
group. There was non-significant difference in the frequency of the homozygous GG
genotype, homozygous mutant AA genotype, heterozygous mutant AG genotype and the
risk value of the (AG+AA) genotype in studied HCC cases with tumor size > 4 cm as
compared to that of control group.
Rs11788747polymorphism on HCC:
There was non-significant difference in the frequency of the heterozygous mutant AG
genotype, homozygous AA genotype, homozygous mutant GG genotype and the risk value
of (AG+AA) genotype for patients with HCC tumor size size > 4 cm and tumor size < 4
cm as compared to that of control group.

EASL HCC Summit • Geneva, Switzerland • 2-5 February, 2017 237