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P06.09-YI

THROMBIN GENERATION TEST AND RISK OF PORTAL
VEIN THROMBOSIS IN PATIENTS WITH LIVER
CIRRHOSIS AND HEPATOCELLULAR CARCINOMA.

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Alberto Zanetto , Alessandro Vitale , Umberto Cillo , Sabrina Gavasso , Paolo
Simioni , Fabio Farinati , Giacomo Germani , Alberto Ferrarese , Martina
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Gambato , Francesco P. Russo , Patrizia Burra , Marco Senzolo 1
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1 Surgery, Oncology and Gastroenterology, Multivisceral Transplant Unit, Surgery, Oncology
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and Gastroenterology, Hepatobiliary Surgery and Liver Transplantation Unit, Medicine, Padua
University Hospital, V Chair of Internal Medicine, Padua, Italy
Corresponding author’s email: alberto.zanetto@yahoo.it
Introduction: Studies that explore the pro-thrombotic state associated with neoplastic
disease and its correlation with the risk of developing portal vein thrombosis (PVT) in
patients with hepatocellular carcinoma (HCC) are lacking.
Aims: The aim of the present study was to evaluate the pro-thrombotic role of HCC in ePOSTER ABSTRACTS
cirrhotic patients as well as to correlate coagulation profile of these patients with PVT
incidence.
Material and Methods: Cirrhotic patients with and without HCC were prospectively
enrolled in the study. All patients underwent platelet count, determination of pro and
anticoagulant factors, thrombingeneration (TG) test [with and without thrombomodulin
(TG)]. During follow-up, PVT onset in both patients with and without HCC was recorded.

Results: 76 cirrhotic patients, 41 with HCC and 35 without HCC, were enrolled. Forty-
eight healthy volunteers were included as the control group. Volume of active HCC was >5
cm in 22 patients. Levels of pro and anticoagulation factors were similar between patients
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with and without HCC, but fibrinogen was increased in HCC patients with active volume
>5cm HCC compared to those with <5cm HCC bulk (350±124mg/dL vs 237±100mg/
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dL) and to cirrhotics without HCC (261±126mg/dL) (p=0,006). Platelet count was
significantly increased in HCC patients compared to non-HCC patients. Endogenous
thrombin potential (ETP) and lag time of TG were higher (p<0.001) and lower (p<0.005)
in HCC patients in comparison to patients without HCC, respectively. Patients with HCC
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>5 cm showed a significant increase of ETP when compared to HCC <5cm (p<0.01).
Correlation between ETP and fibrinogen plasmatic level was found in HCC (r=0.730,
EASL HCC Summit • Geneva, Switzerland • 2-5 February, 2017 239