Page 244 - index.html

and lymphocytic mtDNA deletions; however, this correlation did not reach statistical
significance.
Also, the median survival time for HCC patients with high mtDNA deletions (ΔCt ≥3.9)
was significantly shorter (5.7+ 0.6 months) than those patients with low mtDNA deletions
frequency (11.9+ 0.04 months) (fig.).

Conclusions: This is the first study to our knowledge that explored mtDNA deletions
and folate status in Egyptian patients with HCV related HCC and is the first to evaluate
mtDNA deletions as a diagnostic marker for HCC at a cutoff value of 2.65 (ΔCt) with
a sensitivity of 82% and a specificity of 60%. Our findings implied a causal relationship
between folate deficiency and mtDNA deletions frequency among Egyptian patients with
HCC. Moreover, mtDNA deletions correlated with the clinic-pathological features and
poor survival in HCC patients.

Figure:

ePOSTER ABSTRACTS

Disclosure of Interest: None Declared

244 Programme & Abstracts • HCC Summit