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predictive power of CTC status was independent of R1. Microscopic vascular invasion
(V1) was equally distributed between patients with and without CTC (4/9 vs. 17/47,
p=0.639), and showed no correlation with RFS (HR=0.8, p=0.634).

Conclusions: Bloodstream detection of CTC prior to surgery discloses an elevated HCC
recurrence risk, and a shorter RFS after curative resection, independent of vascular invasion
(V1) or resection margins (R1). Thus, CTC could serve as biomarker for systemic disease,
and to identify patients urgently needing adjuvant systemic therapy. To our knowledge,
this is the first study demonstrating a clinical impact of CTC detection as liquid biopsy in
Western patients with early HCC.

Disclosure of Interest: None Declared

ePOSTER ABSTRACTS

250 Programme & Abstracts • HCC Summit